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Additional studies have shown that spinal fusion may result in degeneration of adjacent discs and lead to further discogenic pain, herniation, stenosis or spondylosis, suggesting that improvements in surgical interventions for back pain are necessary (Ghiselli et al., 2004)

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No one has tested whether the effects are additive, synergistic, or negligible when combined

Kitajima S, Morimoto M, Sagara E et al (2001) Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice

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A 10 mg vial covers 20 weeks at 0.5 mg, 10 weeks at 1 mg, 5 weeks at 2 mg, and about 2.5 weeks at 4 mg weekly