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Footnotes Edited by: Emanuele Micaglio, IRCCS San Donato Polyclinic, Italy Reviewed by: Runzhe Xu, University of Texas Southwestern Medical Center, United States Husain Alkhaldy, King Khalid University, Saudi Arabia Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation

Reports of stability in gastric juice are not the same as systemic bioavailability, and routes of administration in published rodent work include intraperitoneal, oral (drinking water), and topical comparisons across routes are not always controlled in primary studies (Cerovecki et al., 2010)

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