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Collectively, these factors highlight the need for carefully designed therapies that can selectively target GSH in tumors while minimizing toxicity and overcoming adaptive resistance mechanisms

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress

Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals

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If generalized urticaria or other allergic symptoms occur during oral acetylcysteine therapy, the drug should be discontinued unless it is considered essential and the allergic symptoms can be otherwise controlled