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The NRTI 3-deoxy-3-fluorothymidine ( alovudine or FLT), known for its high toxicity, can cause DNA fragmentation and induce apoptosis (Sundseth et al., 1996)

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The following diagram should serve to illustrate this

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[Google Scholar] 73.Ghezelbash B., Shahrokhi N., Khaksari M., Asadikaram G., Shahrokhi M., Shirazpour S

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Clin Neurophysiol 112 : 18811887 Kosek E et al

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Non-modifiable factors include age, gender, family history of cancer, and having a GST mutation

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Reduced glutathione (GSH) is a major intracellular antioxidant neutralizing free radicals and detoxifying electrophiles

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