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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

GSSG is found mainly extracellularly

Erythrocyte glutathione transferase: a novel biomarker to check environmental pollution hazardous for humans

KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD

No.: CD005228

Synthesis of ROS-sensitive polymers (P1) To a solution of 1 h,1 h,10 h,10h-perfluoro-1,10-decanediol (0.62 g, 1.35 mmol) and ROS sensitive molecular (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 mL), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.63 g, 2.83 mmol) was quickly added