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Moreover, SHMT-mediated one-carbon metabolism critically influences liver diseases (e.g., non-alcoholic fatty liver disease, steatohepatitis), inflammatory disorders (e.g., skin inflammation, osteoarthritis), and neurological diseases (e.g., schizophrenia, hypomyelinating leukodystrophy, stroke)

The clinical cure rates and statistical outcome appear in the table below: An open label bacteriologic study of ceftriaxone without a comparator enrolled 108 pediatric patients, 79 of whom had positive baseline cultures for one or more of the common pathogens

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doi: 10.1007/s592-001-8076-6

Sci Rep 12 , 12548 (2022)