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This means the FDA recognizes that AOD 9604 is safe under conditions of intended use

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Potential Cartilage Protection: Some preliminary data suggests peptides derived from growth hormone may also support cartilage health, although more research is necessary to confirm AOD-9604s specific benefits in this area

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

If you are still losing weight steadily on Retatrutide alone, there is no urgent reason to add a second compound