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Other recently suggested Nrf2 activators, such as the cell-permeable alkylating agent, dimethyl itaconate (Mills et al

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By contrast, non-viral vectors, including liposomes and polymeric nanoparticles, provide improved biocompatibility and lower immunogenicity, although often at the expense of reduced transfection efficiency (111)

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The enzyme that produces NAPQI, CYP2E1, is an inducible enzyme and thus, with other substances such as ethanol, can be induced and possibly create more NAPQI and liver injury on its own