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The biological importance of these cell death pathways is underscored by their potential implications for therapeutic strategies, especially in cancer treatment, where targeting these pathways could improve the effectiveness of therapies ( SLC7A11 is becoming increasingly recognized as a crucial factor in both the ferroptosis and disulfidptosis, affecting how cells respond to oxidative stress and metabolic challenges

Within cells, CYPs are predominately membrane-bound on the ER or mitochondria, with the ability to move along the membrane surface as the catalytic domain remains on the cytosolic side but is anchored by the N-terminal transmembrane on the luminal side (rejber et al., 2018)

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