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In a placebo-controlled pilot study, 30 patients received 1 million IU/day subcutaneous IL-2 every other day for 2 weeks, which was followed by a 2-week break, and this 4-week period was repeated twice ( post hoc per-protocol analysis which excluded patients from two sites, where the SRI-4 response rate was 100% in the placebo group showed a statistically significant difference in connection with the primary endpoint, which encourages further investigations (86)

2020 Jul;45(7):1461-1480

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Int J Mol Sci 25:5548 [DOI] [PMC free article] [PubMed] [Google Scholar] lter I, Akyl S, Demirel Z, Ko M, Conk-Dalay M, Kaymak-Ertekin F (2018) Optimization of phycocyanin extraction from Spirulina platensis using different techniques

doi: 10.1056/NEJMoa0808431