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Taken together, the preclinical neurorehabilitation evidence in 5.6 provides a coherent, biologically plausible framework in which polyphenols dampen maladaptive neuroinflammation and oxidative injury, stabilize synaptic and metabolic substrates, and thereby amplify the motor benefits of rehabilitation training, a framework that is mechanistically strong in animals, but that appropriately supports hypothesisdriven, carefully staged human neurorehabilitation trials rather than immediate guidelinelevel recommendations

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Although additional studies are needed, these data support the presence of altered innate immune function in PD

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10.1038/s41598-019-52535-5 202 ZengZ.ChenZ.XuS.ZhangQ.WangX.GaoY.et al (2016)