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Study design: This review article included 18 RCTs with 1,090 participants

Wise LA, Wesselink AK, Tucker KL, et al

This disparity is ascribed to variations in screening methodologies (eg, prevalent prostate-specific antigen [PSA] testing in affluent nations resulting in overdiagnosis), lifestyle determinants (eg, Western diets abundant in red meat and fat, obesity), aging demographics, and genetic predisposition (eg, elevated risk in populations of African descent)