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If your chronic fatigue seems to get better only with adenosyl B12 (and not with methyl B12), its possible that you have some rare condition preventing your body from the inter-conversion

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Omeprazole at oral doses up to 138 mg/kg/day in rats (about 34 times the human dose of 40 mg/day on a body surface area basis) was found to have no effect on reproductive performance of parental animals

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