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Management generally lasts for up to 8 h, depending on the indication, and may be accomplished 1 to 3 times on a daily basis [32]

For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)

B12 is important during pregnancy, but dosing should be coordinated

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NGF and its receptor TrkA are implicated in psychiatric disorders such as depression and schizophrenia, where altered brain levels of neurotrophins are commonly observed (Ciafr et al., 2020)