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Acknowledgements This study was supported by Italian Ministry of University and Scientific Research [P.R.I.N

PMID: 30854646

These results are consistent with previous reports 49 , UVB irradiation induced increased expression of pro-apoptotic proteins Bax and caspase-3 in concert with the repression of antiapoptotic proteins Bcl-2, while accompanied by collagen loss and an increase of MMPs

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Acta Pharmacol Sinica

While the threshold of UA levels that demonstrate significant anti-oxidant and anti-inflammatory properties remains unknown, studies have shown that within the physiological range in human blood, UA exhibits a dose-dependent anti-inflammatory effect [53]