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However, another study using a comparable model reported elevated cytokine and oxidative stress markers in the cortex and hippocampus without detectable changes in neurogenesis ( 6 Mechanisms of chronic stress-induced neuronal dysfunction 6.1 Neuroinflammation Neuroinflammation refers to immune activation and inflammatory responses within the central nervous system (CNS), typically involving sustained activation of microglia and astrocytes as well as excessive release of proinflammatory cytokines (Sotzny et al., 2018), increased numbers of activated CD8 + cytotoxic T cells (Rivas et al., 2018), and elevated levels of multiple proinflammatory cytokines (Montoya et al., 2017)

We also demonstrate a novel method for creating glutathione-laden PEGDA microspheres using reverse-phase emulsion polymerization

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7.5 Microglia Brain-resident macrophages engage in debris engulfment and cytokine release, steering innate defense within CNS insults, ultimately tipping the balance toward either neuronal rescue or damage (Prinz et al., 2019)

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To finish, I would like to point readers also to the wide diversity of ETCs across living systems introduced briefly with further reading in [1], and to the surge in medical research publications reporting measurement of bioenergetics parameters in mammalian cells