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Therefore, extensive in vitro and in vivo studies are required to determine the toxicology, tolerability, and pharmacokinetic profiles

The dismutation of O 2 . results in the formation of hydrogen peroxide (H 2 O 2 ), which can lead to elevated levels of other potentially harmful reactive oxygen and nitrogen species (ROS, RNS) 2

Capgermacrenes A and B, bioactive secondary metabolites from a bornean soft coral, Capnella sp

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None of them evaluated the long-term toxicity, nor did they conduct gene knockdown or overexpression experiments to verify the regulatory mechanisms of natural products (Wang et al., 2023c