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The investigation carried out on piglet jejunal epithelial cells, IPEC-J2, treated with different concentrations of S-methylmethionine sulfonium chloride has demonstrated that vitamin U could stimulate the expression of Mucin-2 (MUC2), epidermal growth factor (EGF), glucagon-like peptide-2 (GLP-2) and insulin-like growth factor-1 (IGF-1), while inhibit the expression of transforming growth factor beta (TGF-1) in both mRNA and protein level that may great importance to repair injury and maintain the intestinal mucosa barrier, and promote intestinal development (Yang et al., 2022)

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Zhao P, Jin Z, Chen Q, Yang T, Chen D, Meng J, Lu X, Gu Z, He Q

For example, arachidonate 12-lipoxygenase, 12S type (ALOX12) inactivation abrogated p53-mediated ferroptosis in cancer cells, and ALOX12 also nullified p53-dependent inhibition of tumor growth in xenograft model mice[40]