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Nucleoside DNMTi is a cytosine nucleoside analog that either directly integrates into DNA sequences in the form of triphosphate to inhibit DNA replication or binds to DNMT covalently to degrade DNMT

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[8] After export, the conjugation products are converted into mercapturic acids and excreted via the urine or bile

The chronic state of neuroinflammation thus creates an environment that is detrimental to synaptic function and plasticity, contributing to the cognitive and emotional deficits observed in individuals with chronic alcohol use

The blocking-labeling assay in sandwich cultures was performed as for the regular neuronal cultures (see Blocking-labeling assay and live treatments, above)