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among downregulatedShmt2, Slc25a5, Fabp5, Tm4sf1

Olyaei AJ, de Mattos AM, Bennett WM (2001) Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies

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The AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i^CHj-NH^-His-Pro-Phe (SEQ ID NO: 1)) As anticipated from the in- vitro blood stability data, D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats

Examples include: Antimetabolites: Drugs like methotrexate, which block DNA synthesis, can be lessened by high B12 levels