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IS-mediated AHR binds to NF-B p65 subunit and leads to mutual inhibition of AHR and NF-B, which suppresses the production of TNF- in macrophages of CKD patients

Beyond QT syndromes, catecholaminergic polymorphic ventricular tachycardia (CPVT) models carrying RYR2 or CASQ2 mutations show spontaneous Ca waves and DADs under adrenergic stimulation, ameliorated by dantrolene or gene therapy 19,109 , and Brugada syndrome ( SCN5A ) models display reduced sodium currents, impaired conduction, and phase 2 reentry-like abnormalities 110