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Needle trauma triggers localized vascular disruption and mast cell degranulation, releasing histamine and prostaglandins that produce erythema (redness) and edema (swelling) within minutes

Steroids can help in the normalization of these laboratory abnormalities in asymptomatic patients with elevated aminotransferases

DOI:10.31579/2834-5126/056 Copyright: 2024, Bon E.I

at some levels it acts as a defence mechanism but in chronic inflammation it is rather proinflammatory

This cycle is shown below, taken from a 2005 AJKD paper by Humphreys et al

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