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Th cells, including T helper 1 (Th1), T helper 2 (Th2), T helper 9 (Th9), and T helper 17 (Th17) cells, are key regulators of the immune system

This augments mitochondrial membrane potential, which decreases the rate of electron transfer through the ETC leading to electron leak and exacerbated ROS generation

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It was hypothesized during this investigation that these components might be "somatomedins," leading to the designation of these compounds as "insulin-like growth factors." (1) Further explorations into the insulin-like growth factors involved gene-targeting approaches to potentially enhance their bioavailability and potency

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Rev Clin Exp Hematol 7(2):160-90, 2003