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doi: 10.3389/fphar.2025.1525529 Received 09 November 2024 Accepted 21 March 2025 Published 17 April 2025 Volume 16 - 2025 Edited by William Chi-Shing Tai, Hong Kong Polytechnic University, Hong Kong SAR, China Reviewed by Yanwen Chen, University of Pittsburgh, United States Yasmina Mohammed Abd-Elhakim, Zagazig University, Egypt Sara Taha Elazab, Mansoura University, Egypt Priyanka N

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In addition, luteolin targets the prostaglandin E 2 (PGE 2 ) pathway, which is a central contributor to EMs-associated pain and disease progression, by upregulating 15-hydroxyprostaglandin dehydrogenase (HPGD), the rate-limiting enzyme responsible for catabolizing PGE 2 into inactive metabolites

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