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CircRHOT1 has been found to play a key role in the development of multiple types of diseases, such as HCC (Wang et al., 2019b), osteoarthritis (Man et al., 2022), and NSCLC (Ren et al., 2021)

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It offers therapeutic benefits for conditions like Parkinsons and Alzheimers disease by improving mitochondrial activity and nerve repair and aiding stroke recovery

Chakraborty A, Krzyzanski W, Jusko WJ (1999) Mathematical modeling of circadian cortisol concentrations using indirect response models: comparison of several methods