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Talk to a dermatologist if your skin becomes rapidly darker, develops irritation, itching, acne, or if the pigmentation continues despite regular skin care and healthy habits.

Bioavailability in humans ranges from 4% to 10%, depending on the study and formulation

Use of gold nanoparticles in a simple colorimetric and ultrasensitive dynamic light scattering assay: Selective detection of arsenic in groundwater

But individual response varies based on baseline glutathione status, genetic polymorphisms in glutathione synthesis enzymes, and concurrent medications that affect redox balance

Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA, Corvalan AH, Biswal S, Swisher SG , Bekele BN, Minna JD, Stewart DJ, Wistuba II

Sciarretta et al., 2018)