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In some embodiments, the nanoparticle comprises a chemically and/or enzymatically modified lipoprotein (e.g., an apolipoprotein, as described in U.S

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Additionally, Nrf2, a master regulator of antioxidant responses, enhances the expression of key genes involved in antioxidant defense (such as SLC7A11, GPX4, and HO-1) and GSH synthesis, playing a pivotal role in maintaining redox balance and suppressing ferroptosis (Yan et al., 2023)

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McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) REporting recommendations for tumour MARKer prognostic studies (REMARK)