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Mechanistically, TXNIP antagonizes Trx1 by forming a disulfide bond with its Cys32 residue, leading to Trx1 inactivation and increased ROS levels, thereby facilitating lipid peroxidation and ferroptotic signaling

Combined antiangiogenic and antiPD-L1 therapy stimulates tumor immunity through HEV formation

10.1155/2019/8108576 188 LiP.XinH.LuL

5 Glutathione is also crucial for detoxification processes, especially in the liver, and helps regenerate other antioxidants like vitamins C and E

As -ketoglutarate can also be derived from glutamine, it will be of interest to determine whether glutamine also exerts epigenetic regulation of osteoclastogenesis via -ketoglutarate

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