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The therapeutic efficacy of these GSH-responsive platforms depends on the extent to which intracellular GSH levels are sufficiently elevated and spatially restricted within tumor cells relative to surrounding normal tissues

This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]

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In general, the overall trends with small molecule glucuronide substrates were maintained when comparing p NPG and DCF-G processing activity

Avoid vigorous activities: Refrain from intense physical activities for at least 24-48 hours post-treatment