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Gastrointestinal issues: Conditions like Crohns disease, celiac disease, or a history of gastric bypass surgery can impair oral absorption

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the contents are 3x as much as in a normal shot which is just likely to be excessive and result in more being flushed down the lavatory as the rate of loss is higher if you have more in your blood so more isn't necessarily better - and they are also suggesting a really high frequency of use which is also likely to be unnecessary

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Dumping Syndrome Causes Some patients that have had gastrectomies suffer from a condition known as Dumping Syndrome

For people with gastrointestinal issues, oral B12 supplements will not be effective