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Impaired synthesis: Taurine deficiency in animals results in impaired bile acid synthesis.[ref] Gut microbiome and bile acids: A lack of taurine also affects the gut microbiome

This aligns with its role as a bidirectional channel that can facilitate both influx and efflux depending on substrate concentration (118)

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In the IBD model, the sphingosine-1-phosphate receptor 2 (S1PR2)/RhoA/ROCK1 pathway modulates ER stress, affecting vascular endothelial barrier function and classically activated macrophages (M1) macrophage polarization, further promoting intestinal inflammation [87]