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Description

A double-blind, placebo-controlled trial on CB4211, which is an analog (synthetic version) of MOTS-c, found the compound to be "safe and well tolerated" under a single and multiple ascending dose protocol in adult humans

Lescot M, Dhais P, Thijs G, Marchal K, Moreau Y, Van de Peer Y, et al

Further, the rate and type of AEs experienced by the volunteers were indistinguishable from those experienced by the group receiving the placebo

They showed increased OS status in the testes and epididymides of hypertensive rats as evidenced by a significant reduction in total and non-protein thiol levels, glutathione S-transferase (GST) activity with a concomitant increase in DFCH oxidation and TBARS production