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It has also been demonstrated that reduced epidermal thickness, cell damage, impaired barrier function and altered surface characteristics were found in human organ-skin models constructed with premature senescent fibroblasts (80)

Medical and Lifestyle Factors That Increase Bruising Risk Anticoagulant medications, including warfarin, dabigatran, and some antiplatelet agents, increase bleeding tendency at injection sites

Vaillant-BeuchotLMaryAPardossi-PiquardRBourgeoisALauritzenIEysertFet al

Gan RW, Young KA, Zerbe GO, et al

doi: 10.3389/fimmu.2022.812996 40 MysliwiecHHarasim-SymborEBaranASzterling-JaworowskaMMilewskaAJChabowskiAet al

The absence of a plausible interaction mechanism no CYP450 involvement, no blood-sugar effects, and poor oral bioavailability means the theoretical risk is low