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The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response

However, outcome from investigations using mice genetically manipulated for proteins integral or associated with the TJ have not been consistent and have resulted in diverse effects including immune adaptation and tolerance (summarized in Table 2)

They are broken down in the digestive system and will not have the systemic effect that the false theory relies on

In the UK, pregnant women from diverse backgrounds showed detectable urinary DON levels, with South Asian women having higher exposure, primarily from bread consumption [61]

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