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Se observ que los pacientes con anemia perniciosa instaurada mejoraban con la ingesta de hgado, y posteriormente se empezaron a administrar extractos concentrados a partir de hgados animales, y que sirvieron durante aos como la alternativa ms viable para el tratamiento de la enfermedad, hasta que se descubri que era la vitamina B12 la que reverta los sntomas y se trabaj en su sntesis aislada que tuvo lugar hacia mitad- tres cuartos del siglo XX

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Fleming K, Nemanic S, Lhr CV, Terry J, Milovancev M (2019): CT angiography and MRI imaging features do not predict the tumor type and grade of feline injection site sarcoma

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