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This event occurs through epigenetic modification, which represents a rapid and reversible response and involves diverse enzymes including histone (de)methylases, (de)acetylases, and DNA

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The combination of these two measures can reveal a link between cochlear neuropathy and central neural hyperactivity, providing characteristic evidence that cochlear synaptopathyseen as a reduction in wave-I amplitudeis followed by compensatory central gain, reflected in the relatively stable amplitude of wave V 11,45

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( Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase