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You should speak to a clinician before fasting if you have: Diabetes (type 1, type 2 on insulin, or type 2 on sulfonylureas), a history of hypoglycaemia, or poor glucose awareness Pregnancy or breastfeeding Chronic kidney disease , kidney stones, or recurrent dehydration Heart failure, recent cardiac events , unstable angina, or complex cardiovascular disease Eating disorder history (past or present) Adrenal insufficiency or conditions requiring steroid replacement Any condition where dehydration could be dangerous, or where medication timing must be precise Clinical guidance exists specifically to help risk-stratify patients who wish to fast (for example, in cardiovascular disease and diabetes)