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Although cancer tops the list, epigenetics has featured in obesity, metabolic syndromes, and diabetes, aging, cardiovascular disease, kidney and liver diseases, autoimmunity, such as rheumatoid arthritis, allergic diseases, and inflammatory diseases such as Crohns disease and inflammatory bowel disease

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Overall, HIFs are the most sensitive and important nuclear transcription regulators response to hypoxia

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Hong Y, Zou H, Hu Y, Fei F, Liang L, Liu D, et al

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Physiological effects: By expanding blood volume, IV fluids raise blood pressure and improve perfusion (the key goal in shock)Infused water and electrolytes also address deficits (rehydrate tissues, correct Na, K, etc.)

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The infiltration of these xenografts was characterized by NK cells showing expression of several activating receptors and bearing several markers of cytotoxic cells, including perforin, granzyme, tumor necrosis factor (TNF), and interferon (IFN)

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