nayan patel glutathione Episode 85 Featuring World Renown Expert Dr. Patel! Get ready to become a full blown expert on everything Glutathione! Last year at A4M, I was heading to see a speaker Auro Wellness founder, Dr. Nayan

& Shimoda, T

Clinical trials show oral glutathione at 500mg doses reduces melanin index when taken consistently for 8-12 weeks

NNMT inhibitors should reduce NNMT activity in aged muscles such that the NAD+ salvage cycle in aged muscle cells is returned to the functioning observed in young muscle cells

Holy Digestivo (maybe the 75 million Americans with digestive problems need to know this)

For 5-amino-1MQ specifically: Preclinical studies have not prominently described heart rate elevation as a dominant signal The mechanism (NNMT inhibition, NAD+ preservation) does not have the same direct cardiac implications as nuclear receptor agonism Human cardiovascular data at clinically relevant exposures are limited For physicians, the current evidence base does not support a major cardiovascular safety flag, but the limited human dataset means confident statements are premature

Key findings include: GLP3 monotherapy achieved 22.8-24.2% mean weight reduction at 48 weeks in phase 2 obesity trials (8-12 mg doses) Cagrilintide monotherapy produced 10.8% weight loss over 26 weeks in phase 2 studies (2.4 mg dose) CagriSema combination (cagrilintide + semaglutide) achieved 20.4% weight loss at 68 weeks in phase 3 REDEFINE trials Combination approaches consistently outperformed single-agent therapies across multiple dose ranges Studies demonstrated that 100% of participants receiving GLP3 8 mg or higher achieved at least 5% weight loss, with 75-83% achieving 15% or greater weight reduction[9]