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However, knockout mice were not protected from hepatic steatosis induced by a high fat diet, potentially due to decreased fatty acid oxidation caused by a compensatory increase of ACC2, which in turn inhibited mitochondrial -oxidation [58]

Future research should critically evaluate whether sufficient active curcumin (or its metabolites) reaches oral or systemic target tissues at pharmacologically relevant concentrations in humans, and whether observed clinical benefits correlate with biologically plausible exposureresponse relationships

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Without susceptible substrate, the oxidation chemistry cannot proceed regardless of copper availability

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Biochemistry 39 , 1300513011 (2000)