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Addressing underlying autonomic dysfunction can also significantly improve sleep quality

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Mutations in the Golgi zinc transporter ZIP13 cause spondylocheirodysplastic EhlersDanlos syndrome (EDS), a connective-tissue disorder characterized by short stature, hyperextensible skin, joint laxity and skeletal abnormalities 34,35,116,138,139,140,141,142

They advocate for a treatment approach that is: Symptom-led : Recognising that many patients become symptomatic well before their next scheduled dose, meaning they are being under-treated