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" Over-use of parenteral B12 " sounds like an opinion: rather like the " B12 is toxic/carcinogenic/highly addictive " or " the sense of euphoria from self injecting " I had to listen to from various consultants who really should have known better

Citation25,Citation26 To overcome these challenges as well as achieve precise and efficient treatment, Xiang et al developed tumor microenvironment-responsive BTNPs (tma-BTO NPs)

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[28] Because of this mimicry, it is transported freely throughout the body including across the bloodbrain barrier and across the placenta, where it is absorbed by the developing fetus

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But this molecular activity doesn't translate to visible or measurable changes yet