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GHS can mildly increase insulin resistance and glycated hemoglobin (HbA1c) levels over time

Data were compared for basal respiration and maximal respiratory capacity (six replicates per condition, repeated two times)

GH Axis Integrity Assessment Tesamorelin stimulation testing is used in pre-clinical research to assess somatotroph secretory reserve characterising peak GH responses as a functional readout of pituitary GH axis integrity across disease models, ageing paradigms, and pharmacological intervention studies

It is not clear the potential reasons of these discrepancies, although it is interesting that multiple IGF-1 signaling pathway molecules are potentially targeted by one miRNA, and studies are required to investigate its relationship with other miRNAs discussed below