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Additionally, zinc can block NMDA receptors, preventing glutamate from entering cells, thus producing an anxiolytic effect (Dou et al., 2018)

Most studies note diminished prefrontal cortical activity in dorsolateral PFC, ventrolateral PFC, and dorsomedial PFC in depressed bipolar patients compared with either euthymic patients or healthy controls (90, 106, 141, 142)