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1,373 Rs

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5 MichaelisMenten-Kinetics of Pt GSTF8 with flavan-3,3,4-triol (4)

doi: 10.3390/ijms222011264 150 GuerreiroR.WojtasA.BrasJ.CarrasquilloM.RogaevaE.MajounieE.et al

found that calcium/calmodulin-dependent serine protein kinase (Cask), a crucial multidomain scaffold protein at the synapse and in cell junctions (Hsueh, 2006), is the downstream effector in response to the reduction in NAD+ and is also downregulated in the hippocampus during aging (Johnson et al., 2018)

The p53 protein contains 393 amino acids and six structural domains: two N-terminal transactivation domains, a central DNA-binding domain, a proline-rich domain, a tetramerization domain, and a C-terminal domain (Joerger and Fersht, 2016) (Figure 3)