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Mechanistically, Vitamin D 3 acts through multiple pathways in psoriasis ( Figure 3A ) ( Table 3 ): regulating keratinocyte growth and differentiation (87), enhancing antimicrobial barrier function through LL-37 induction (88), suppressing pathogenic Th1/Th17 responses while promoting Tregs (89), and inhibiting DCs and macrophage activation (90)