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These include approaches such as light therapy, pharmacological agents, and behavioral modifications that have shown potential in mitigating the harmful effects of circadian misalignment (Lee et al., 2021

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In a prospective study, Sabate et al.[39] estimated the incidence of acute liver injury due to therapeutic dosages of APAP to be about 10 per million user-years

Consequently, when calculating the volumes of the cavities using the program CASTp with a probe radius of 3 48 , the apo conformation had a cavity volume of ~4883 3 , while the substrate-bound forms exhibited much smaller cavity volumes ranging from 2312 to 2613 3 (Fig

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