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When signaling was removed from all SHH-expressing cells, the NP was smaller in the mutant mice when compared to the control

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Fatigue: Some participants reported fatigue, particularly during the early titration period

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These patients also had higher pH ( P = 0.0223), O 2 pressure ( P = 0.0028), CO 2 tension ( P = 0.0309) and O 2 saturation ( P = 0.0123), compatible with the fact that SEV patients were intubated with mechanical ventilation