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EF-hand domains Highly conserved Ca 2+ -binding domains comprising two helices (E and F after the 5 th and 6 th helices of parvalbumin) that are linked by a short acidic Ca 2+ -binding loop

Siegel, J

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimers disease: role of lipid peroxidation in Alzheimers disease pathogenesis

doi: 10.1038/s41598-023-41291-2 56 AbarikwuSOOnuahCLSinghSK

In the case of LPA signaling, downstream effectors such as PI3K, MAPK, and Rho GTPase orchestrate critical cellular functions, including proliferation, migration, and survival, mirroring the layered architecture of neural networks that process inputs across multiple nodes to derive complex outputs

Result The current investigation revealed that CCl 4 intoxication significantly decreases myocardial CPK and LDH activities after CCl 4 intoxication (Figure 1)