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Cancers arising from tissue with a highly NAPRT are expression completely and irreversibly dependent on the NAPRT-regulated de novo pathway, while cancers deriving from tissues with the low level of NAPRT mainly rely on the NAMPT-mediated NAD + salvage pathway

Jiachun Sun, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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